Skip to main content
| News

University of Basel and RocketVax present new Covid vaccine

22.05.2023

Researchers from the University of Basel have developed a new concept for a Covid vaccine in collaboration with the biotech startup RocketVax. It is based on a modified version of the virus that can no longer replicate. The vaccine can be produced cost-effectively and is simple to store and administer.

Covid vaccine research in the laboratory (image: University of Basel)

The University of Basel and RocketVax, a biotechnology startup also based in Basel, are focusing on a new principle, namely single-cycle viruses, in the development of a new vaccine. According to a press release, the vaccine can simply be stored in a refrigerator. It is administered by nasal drop, which does not require trained medical personnel. In addition, the production method for the vaccine is said to be particularly cost-effective and can be easily adapted to future virus variants.

The vaccine is based on a modified version of the coronavirus produced in a lab setting. However, it is unable to replicate further after entering the human body. “Among other things, we remove a specific gene from the blueprint for the viral envelope”, as study leader Prof. Dr. Thomas Klimkait from the Department of Biomedicine at the University of Basel explains in the press release, adding that: “If this envelope component is missing, no new virus particles can be formed”.

Broad financial support

However, the individual virus components are still produced. The body cells present these on their surface to the immune system, which recognizes the virus building blocks and builds up effective immune protection. The team also removed genes that the virus uses to inhibit the immune response of the cells. A patent application for the concept has now also been submitted by the researchers.

RocketVax collaborated on the development and preclinical studies. For the successful animal experiments with hamsters, the team cooperated with the Friedrich Loeffler Institute in Germany. The partnership is embedded in a research cooperation with University Hospital of Basel and the Swiss Tropical and Public Health Institute (Swiss TPH). The University Hospital of Basel and the Canton of Basel-Stadt provided startup funding for the preclinical research activities in connection with the new vaccine, which were already underway. The project also received financial support from Innosuisse, the Swiss innovation agency.

Share this article

Sign up to receive our newsletter in your inbox.

You may also be interested in

In Muttenz steht die weltweit grösste Anlage zur Produktion von 5-HMF aus Biomasse
Basel Area Business & Innovation

In Muttenz steht die weltweit grösste Anlage zur Produktion von 5-HMF aus Biomasse

Thomas Fischer ist Chief Operating Officer bei der Biotechnologiefirma AVA Biochem in Muttenz.

Read More
Axalta Coating Systems opens regional headquarters in the city of Basel
Basel Area Business & Innovation, Innovation, Invest

Axalta Coating Systems opens regional headquarters in the city of Basel

Philadelphia-based company Axalta Coating Systems, a leading global supplier of liquid and powder coatings is establishing its European business activities...

Read More
BaselArea.swiss welcomes Biopharmaceutical Company Ultragenyx
Basel Area Business & Innovation, Innovation, Invest

BaselArea.swiss welcomes Biopharmaceutical Company Ultragenyx

BaselArea.swiss Economic Promotion is pleased to announce that Ultragenyx, a biopharmaceutical company focused on the development of novel products for...

Read More
«Many start-ups begin under precarious conditions – that doesn’t have to be»
Basel Area Business & Innovation, Invest

«Many start-ups begin under precarious conditions – that doesn’t have to be»

Basel region. The entrepreneur has a large network of contacts that allows him to establish access not only to investors,...

Read More
Basel Area Business & Innovation

«Only when it is shared in the team does an idea take shape»

Hans-Florian Zeilhofer is a surgeon, innovator, scientist and entrepreneur. He has performed pioneering work in many fields of reconstructive facial...

Read More
Pascal Bourquard: «Without roots, we cannot develop»
Basel Area Business & Innovation

Pascal Bourquard: «Without roots, we cannot develop»

«I don’t have any lessons to impart, just the opportunity to share my experience.» It was with these words that...

Read More
1 61 62 63

Do you have a question? We'd like to hear from you.