| News

Researchers in Basel develop dual-virus therapy for cancer

04.03.2021

Researchers at the University of Basel have developed a promising strategy for therapeutic cancer vaccines. They are expanding upon pre-existing vaccines to activate the immune system to fight off tumors using two viruses.

An international research group led by Professor Daniel Pinschewer from the Department of Biomedicine at the University of Basel has developed a new strategy for therapeutic cancer vaccines in animal trials. According to the press release from the university, this uses viruses that have been rendered harmless to transport cancer cells, which then activate the body’s immune system in such a way that it fights the tumor. Pinschewer’s therapy is innovative in its use of two viruses at staggered intervals instead of just one.

The press release explains that this method prevents the body’s innate immune system from attacking the viruses instead of the actual target, the “cargo” with cancer cells. By using two virus transporters one after the other, this effect was achieved in animal tests on mice. The immune system initially only uses killer T-cells to attack the cancer cells that have been introduced, and then attacks the tumor from which these were taken.

Pinschewer is quoted in the press release, saying: “By using two different viruses, one after the other, we focus the triggered immune response on the actual target, the tumor molecule. […] We can’t say anything about the efficacy of our approach in humans as yet […] However, since the therapy with two different viruses works better in mice than the therapy with only one virus, our research results make me optimistic.”

The Biotech company Hookipa Pharma in New York and Vienna, which Pinschewer co-founded, is now investigating the efficacy of this innovative approach to cancer therapy in humans in clinical trials. If the new approach is proven effective, the Basel researchers can also see it being used in combination with existing therapies in order to increase their efficacy.

Share this article

Sign up to receive our newsletter in your inbox.

You may also be interested in

Bottmedical enters the market with innovative braces
Basel Area Business & Innovation, Innovation, Invest

Bottmedical enters the market with innovative braces

The Basel-based startup Bottmedical has developed clear braces made from bio-based polymers. After closing a successful financing round, the company...

Read More
TargImmune raises nearly 18 million Swiss francs
Basel Area Business & Innovation, Innovation, Invest

TargImmune raises nearly 18 million Swiss francs

The Basel-based biotechnology firm TargImmune has raised 17.7 million Swiss francs as part of a financing round. It now intends...

Read More
KetoSwiss launches first product in the USA
Basel Area Business & Innovation, Innovation, Invest

KetoSwiss launches first product in the USA

The Basel-based biotech startup KetoSwiss develops innovative therapies for neurological disorders. Following a successful capital increase, the company now has...

Read More
For Swiss startups, China might be closer than it seems
Basel Area Business & Innovation, Invest

For Swiss startups, China might be closer than it seems

China wants to strengthen domestic demand and be less dependent on imports. This policy has huge implications for the life...

Read More
Basel Area treads unique path
Basel Area Business & Innovation, Innovation, Invest

Basel Area treads unique path

Basel Area is responsible for both location and innovation promotion. This approach, which is unique across Switzerland, is very successful...

Read More
Alentis secures 67 million US dollars
Basel Area Business & Innovation, Innovation, Invest

Alentis secures 67 million US dollars

The Basel-based biotechnology company Alentis Therapeutics has secured 67 million US dollars in a series B funding round. The funds...

Read More
1 2 3 46

Do you have a question? We'd like to hear from you.